Clonazolam also known as clonitrazolam is a drug of the triazolobenzodiazepine TBZD class, which are benzodiazepines BZDs fused with a triazole ring. It has had very little research done about its effects and metabolism, and has been sold online as a designer drug.
The synthesis of clonazolam was first reported in and the drug was described as the most active compound in the series tested. Clonazolam is reported to be highly potent, and concerns have been raised that clonazolam and flubromazolam in particular may pose comparatively higher risks than other designer benzodiazepines, due to their ability to produce strong sedation and amnesia at oral doses of as little as 0.
In the UK, clonazolam has been classified as a Class C drug by the May amendment to The Misuse of Drugs Act along with several other designer benzodiazepine drugs.
Virginia State Law has declared all of the following are now schedule I: clonazolametizolamflualprazolamflubromazolamand flubromazepam. Sweden's public health agency suggested classifying clonazolam as a hazardous substance on June 1, Clonazolam's effects are similar to other benzodiazepines, such as anxiolysisdisinhibition, lethargy, muscle relaxation, and euphoria. While no dose of clonazolam is considered "safe" due to its lack of research and extreme potency, doses higher than 0.
The effects of a benzodiazepine overdose include sedation, confusion, insufficient breathing, loss of consciousness, and death. Because dependence can occur in a short period of time, or even with a large initial dose, withdrawal symptoms may occur acutely, following the period of intoxication. These include seizures and can result in death. From Wikipedia, the free encyclopedia. Not to be confused with clonazepam or clorazolam. IUPAC name.
Interactive image. Forensic Toxicology. Analytical and Bioanalytical Chemistry. Toxicologie Analytique et Clinique. Drug Testing and Analysis. Forensic Science International. Journal of Medicinal Chemistry. World Psychiatry. Schedule I". Retrieved 6 August Cloxazolam Flutazolam Haloxazolam Mexazolam Oxazolam.
Bentazepam Clotiazepam. Olanzapine Telenzepine. Alprazolam triazolobenzophenone Avizafone Rilmazafone. Etomidate Metomidate Propoxate.A rather novel Benzodiazepine that is structurally quite close to Alprazolam.
Research chemicals are drugs with relatively little history of human use, and thus particular care should be taken if choosing to ingest them. Drugs marked as tentative are those our team wasn't able to find much reliable information about. This is often because the drug is very new. Information listed under these drugs should not be entirely trusted.
These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken. They would not exist without him. Factsheet data is now cached locally - if you have visited a page you can now view it offline! Are you a harm reduction organisation using TripSit? Let us know about you! Summary A rather novel Benzodiazepine that is structurally quite close to Alprazolam. Benzodiazepine Benzodiazepines are generally hypnotic or anxiolytic depressant drugs.
Read more on TripSit Wiki Research Chemical Research chemicals are drugs with relatively little history of human use, and thus particular care should be taken if choosing to ingest them. Tentative Drugs marked as tentative are those our team wasn't able to find much reliable information about. Habit-forming These drugs pose a higher risk of causing habit forming behaviour, take particular care with the amount and frequency they are taken.
Oral Light 0. Avoid All other CNS depressants. The two substances potentiate each other strongly and unpredictably, very rapidly leading to unconsciousness. While unconscious, vomit aspiration is a risk if not placed in the recovery position. Blacking out and memory loss is almost certain.
Vomit aspiration a risk when passed out, lay down in recovery position if ingested. Caution Ketamine Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. MXE Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses.
Place affected patients in the recovery position to prevent vomit aspiration from excess. DXM Small doses of benzos can end a bad trip, but both substances potentiate the ataxia and sedation caused by the other and this can lead to unexpected loss of consciousness at high doses. Unsafe PCP Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses.
Memory blackouts are likely.Flubromazolam has been classified as an illegal substance in Sweden after seizures by customs and police, as well as indications from the EMCDDA of wider use as a recreational drug. Flubromazolam is illegal in Switzerland as of December In the UK, flubromazolam has been classified as a Class C drug by the May amendment to The Misuse of Drugs Act along with several other designer benzodiazepine drugs.
From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. Stereospecific anxiolytic and anticonvulsant agents with reduced muscle-relaxant, sedative-hypnotic and ataxic effects. Retrieved 6 August Journal of Medicinal Chemistry. Cayman Chemical. Retrieved 20 November Forensic Toxicology.
Toxicologie Analytique et Clinique. Drug Testing and Analysis. Forensic Science International. World Psychiatry. Clinical Toxicology.
Der Bundesrat. Cloxazolam Flutazolam Haloxazolam Mexazolam Oxazolam. Bentazepam Clotiazepam. Olanzapine Telenzepine. Alprazolam triazolobenzophenone Avizafone Rilmazafone. GABA A receptor positive modulators.
Etomidate Metomidate Propoxate. Fospropofol Propofol Thymol. Glutethimide Methyprylon Piperidione Pyrithyldione. Namespaces Article Talk. Views Read Edit View history. Help Learn to edit Community portal Recent changes Upload file. Download as PDF Printable version.Bromazepamsold under many brand names, is a benzodiazepine.
It is mainly an anti-anxiety agent with similar side effects to diazepam Valium. In addition to being used to treat anxiety or panic states, bromazepam may be used as a premedicant prior to minor surgery. It was patented in by Roche and approved for medical use in Treatment of severe anxiety. Bromazepam is a "classical" benzodiazepine; other classical benzodiazepines include: diazepamclonazepamoxazepamlorazepamchlordiazepoxidenitrazepamflurazepamand clorazepate.
It acts as a positive modulatorincreasing the receptors' response when activated by GABA itself or an agonist such as alcohol. After night time administration of bromazepam a highly significant reduction of gastric acid secretion occurs during sleep followed by a highly significant rebound in gastric acid production the following day.
Bromazepam alters the electrical status of the brain causing an increase in beta activity and a decrease in alpha activity in EEG recordings. Bromazepam is reported to be metabolized by a hepatic enzyme belonging to the Cytochrome P family of enzymes. The major metabolite of bromazepam is hydroxybromazepam,  which is an active agent too and has a half-life approximately equal to that of bromazepam. Bromazepam is similar in side effects to other benzodiazepines.
The most common side effects reported are drowsiness, sedation, ataxiamemory impairment, and dizziness. In combination with alcohol, impairments in learning capacity became even more pronounced. On occasion, benzodiazepines can induce extreme alterations in memory such as anterograde amnesia and amnesic automatismwhich may have medico-legal consequences.
Such reactions occur usually only at the higher dose end of the prescribing spectrum. Very rarely, dystonia can develop. Leukopenia and liver-damage of the cholestatic type with or without jaundice icterus have additionally been seen; the original manufacturer Roche recommends regular laboratory examinations to be performed routinely.
Ambulatory patients should be warned that bromazepam may impair the ability to drive vehicles and to operate machinery. The impairment is worsened by consumption of alcohol, because both act as central nervous system depressants. During the course of therapy, tolerance to the sedative effect usually develops. As with all medication, the frequency and seriousness of side-effects varies greatly depending on quantities consumed. Moreover, side-effects other than drowsiness, dizziness and ataxia seem to be rare  and not experienced by more than a few percent of users.
The use of other, comparable medication seems to display an identically moderate side-effect profile  '  '. Prolonged use of bromazepam can cause tolerance and may lead to both physical and psychological dependence on the drug, and as a result, it is a medication which is controlled by international law. It is nonetheless important to note that dependence, long-term use and misuse occur in a minority of cases    and are not representative of most patients' experience with this type of medication  '.
It shares with other benzodiazepines the risk of abuse, misuse, psychological dependence or physical dependence. Those whose dose was gradually reduced experienced no withdrawal. Patients treated with bromazepam for generalised anxiety disorder were found to experience withdrawal symptoms such as a worsening of anxiety, as well as the development of physical withdrawal symptoms when abruptly withdrawn bromazepam. Animal studies have shown that chronic administration of diazepam or bromazepam causes a decrease in spontaneous locomotor activity, decreased turnover of noradrenaline and dopamine and serotonin, increased activity of tyrosine hydroxylase and increased levels of the catecholamines.Bromazolam XLI is a benzodiazepine derivative which was first synthesised inbut was never marketed.
From Wikipedia, the free encyclopedia. IUPAC name. Interactive image. Drug Testing and Analysis. International Journal of Medicinal Chemistry.
Cloxazolam Flutazolam Haloxazolam Mexazolam Oxazolam. Bentazepam Clotiazepam. Olanzapine Telenzepine. Alprazolam triazolobenzophenone Avizafone Rilmazafone. Etomidate Metomidate Propoxate. Glutethimide Methyprylon Pyrithyldione Piperidione.
Serotonin antagonists and reuptake inhibitors Etoperidone Nefazodone Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramineetc. Tetracyclic antidepressants Mianserin Mirtazapineetc. Typical antipsychotics Chlorpromazine Thioridazineetc.The dark side of Benzodiazepine
Atypical antipsychotics Olanzapine Quetiapine Risperidoneetc. Trazodone Tricyclic antidepressants Amitriptyline Doxepin Trimipramineetc. Agomelatine Melatonin Ramelteon Tasimelteon. Almorexant Filorexant Lemborexant Suvorexant. Gabapentin Gabapentin enacarbil Mirogabalin Phenibut Pregabalin. GABA A receptor positive modulators.
Fospropofol Propofol Thymol. Glutethimide Methyprylon Piperidione Pyrithyldione. Namespaces Article Talk.The below tables contain a sample list of benzodiazepines and benzodiazepine analogs that are commonly prescribed, with their basic pharmacological characteristics, such as half-life and equivalent doses to other benzodiazepinesalso listed, along with their trade names and primary uses.
The elimination half-life is how long it takes for half of the drug to be eliminated by the body. Benzodiazepines generally share the same pharmacological properties, such as anxiolyticsedativehypnoticskeletal muscle relaxantamnesicand anticonvulsant effects. Variation in potency of certain effects may exist amongst individual benzodiazepines. Some benzodiazepines produce active metabolites. Active metabolites are produced when a person's body metabolizes the drug into compounds that share a similar pharmacological profile to the parent compound and thus are relevant when calculating how long the pharmacological effects of a drug will last.
Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and chlordiazepoxideare often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for insomnia due to their lesser hangover effect.
It is fairly important to note that elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals.
Individuals with an impaired liver also metabolize benzodiazepines more slowly. Many doctors [ who? Thus, the approximate equivalent of doses below may need to be adjusted accordingly in individuals on short acting benzodiazepines who metabolize long-acting benzodiazepines more slowly and vice versa. The changes are most notable with long acting benzodiazepines as these are prone to significant accumulation in such individuals and can lead to withdrawal symptoms.
Data in the table below is taken from the Ashton "Benzodiazepine Equivalency Table". The UK's House of Commons has attempted to get a two to four week limit mandate for prescribing benzodiazepines to replace the two to four week benzodiazepine prescribing guidelines, which are merely recommended. A large number of benzodiazepine derivatives have been synthesised and their structure-activity relationships explored in detail. While binding or activity data is available for most of these compounds also, the assay conditions vary between sources, meaning that in many cases the values are not suitable for a direct comparison.
Many older sources used animal measures of activity i. From Wikipedia, the free encyclopedia. Redirected from List of benzodiazepine designer drugs. Wikimedia list article. The core structure of benzodiazepines. Clinical observation notating the patient's oxygen levels, respiratory, heart and blood pressure rates are used, as they are much safer than the potential seizure effects from flumazenil.
Supportive care to mediate any problems resulting from abnormal rates of the pulmonary, respiratory, and cardiovascular systems is typically the only treatment that is required in benzodiazepine-only overdoses.
British Journal of Clinical Pharmacology. Archived from the original on Retrieved Clinical geriatric psychopharmacology 4th ed. Drug Safety.
Acta Neurologica Scandinavica. When and what to use". April Drug and Alcohol Services South Australia. June Drug Testing and Analysis.But if we stick to the profit, then there should be for sure a maximum number of picks made or units that are used.
I believe that no one with a normal life can follow a tipster that makes 1000 picks per month. My opinion is that there should be a margin of 100-200 picks at the most per month. Also no one can write analysis of 1000 picks per month. These analysis are most of the time without any useful info concentrating on numbers and stats.
And from my humility, I sincerely believe that what you must change is your way of correcting errors, I explain it: I remember how, until recently, for example, I found lines that dind't appear in a very important game, such as over 2.
However, now you tell me that you can't make it because it is something that you can't control because it is automatic, and why before you could, you can't or you don't want?.
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Media outlets nationwide turn to a handful of people for insight and predictions into point spreads and odds. And the man they look to more than any other is RJ Bell, a self-proclaimed modern-day Jimmy the Greek. Various titles, some generous and others outright falsebetting expert, professional handicapper, Vegas oddsmakerare used to identify Bell when he is interviewed, but his role as head of Pregame.
Pregame, which Bell started in 2005, sells sports-betting picks. Bell says they are winning pro bettors, and by paying for their advice, the implication is that you will win, too. After all, they do this for a living. Mainstream media now brings the heads of these services on air and passes them off as analysts, affording people like Bell streams of new customers and free advertising a salesman could scarcely imagine. Scribes and sportscasters alike present Bell as the oracle of Las Vegas.
You can hear him on Stephen A. A few years ago, he wrote a regular betting column for Grantland. On Twitter, his followers number more than 117,000.